Lack of experience - Draw on experiences other than work such as that gained in other settings, through hobbies, or in volunteer experiences. Consider skills that you have that are similar and can be applied to the experience you lack. Also, stress that learning new things is important aspect you wish to develop & pursue.
Lack of education/qualifications - Emphasize skills you have developed through on-the-job training or other experiences, as well as self-taught knowledge and skills. Especially skills you have developed on your own accord.
Poor academics - Present examples of learning activities in which you have performed well. Point out other accomplishments and emphasise how they relate to the position you are seeking.
Job Hopping - Emphasise what you learned from your various jobs, especially as it might pertain to the job for which you are interviewing. Show how your job changes illustrate a pattern of professional growth. Explain how this job fits with your interests and goals.
Gaps in employment - Describe what you did during the gap in your employment history and what you did and learned during this period of time. If you were fired or quit a job, share what you learned from the experiences.